Regulation of the Locus of Enterocyte Effacement in Attaching and Effacing Pathogens
نویسندگان
چکیده
منابع مشابه
Characterization of two non-locus of enterocyte effacement-encoded type III-translocated effectors, NleC and NleD, in attaching and effacing pathogens.
Intestinal colonization by enteropathogenic and enterohemorrhagic Escherichia coli requires the locus of enterocyte effacement-encoded type III secretion system. We report that NleC and NleD are translocated into host cells via this system. Deletion mutants induced attaching and effacing lesions in vitro, while infection of calves or lambs showed that neither gene was required for colonization.
متن کاملThe locus of enterocyte effacement pathogenicity island of Shiga toxin-producing Escherichia coli O157:H7 and other attaching and effacing E. coli.
INTRODUCTION Shiga toxin-producing E. coil (STEC) O157:H7 and enteropathogenic E. coil (EPEC) produce a characteristic histopathology on intestinal epithelial cells known as attaching and effacing (AlE). The characteristics of this pattern includes effacement of epithelial cell microvilli and intimate adherence between the bacterium and the epithelial cell membrane. Marked cytoskeletal changes ...
متن کاملThe cloned locus of enterocyte effacement from enterohemorrhagic Escherichia coli O157:H7 is unable to confer the attaching and effacing phenotype upon E. coli K-12.
The locus of enterocyte effacement (LEE) pathogenicity island of enterohemorrhagic Escherichia coli (EHEC) O157:H7 possesses the same genes in identical order and orientation as the LEE of enteropathogenic E. coli (EPEC) O127:H6 but is unable to form attaching and effacing (A/E) lesions or to secrete Esp proteins when it is cloned in an E. coli K-12 background. The A/E phenotype could not be re...
متن کاملRegulation of type III secretion hierarchy of translocators and effectors in attaching and effacing bacterial pathogens.
Human enteropathogenic Escherichia coli (EPEC), enterohemorrhagic E. coli (EHEC), and the mouse pathogen Citrobacter rodentium (CR) belong to the family of attaching and effacing (A/E) bacterial pathogens. They possess the locus of enterocyte effacement (LEE) pathogenicity island, which encodes a type III secretion system. These pathogens secrete a number of proteins into culture media, includi...
متن کاملQseA and GrlR/GrlA regulation of the locus of enterocyte effacement genes in enterohemorrhagic Escherichia coli.
Transcription of the locus of enterocyte effacement (LEE) genes in enterohemorrhagic Escherichia coli (EHEC) is regulated by the LEE-encoded Ler and GrlR/GrlA proteins as well as the non-LEE-encoded regulator QseA. This work demonstrates that GrlR/GrlA activate LEE2 transcription in a Ler-independent fashion, whereas transcription of grlRA is activated by QseA in both Ler-dependent and -indepen...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 2018
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.00336-17